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  • Non-Clinical ADME
  • Services

Services

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Class Element technology
Physicochemical properties Solubility (kinetic, thermodynamic)
Chemical stability (Buffer, Biorelevant media)
Thermodynamic solubility
Permeability PAMPA assay
Caco-2 cells permeability
Protein binding Plasma (Equilibrium dialysis, Ultrafiltration)
Albumin, Alpha-glycoprotein (Equilibrium dialysis, Ultrafiltration)
Microsomal binding
Metabolism study Plasma stability
Microsomal stability
S9 stability
Hepatocyte stability
Metabolite profiling and Met ID (in vitro)
Metabolite profiling and Met ID (in vivo)
Reactive metabolite formation (GSH trapping)
CYP Phenotyping (CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 3A4/5)
UGT Phenotyping (UGT1A1, 1A3, 1A4, 1A6, 1A9, 2B7, 2B15)
Phenotyping_metabolite formation
Non-CYP (FMO, CES, NAT, SULT 외)
Transport study ABC transport phenotyping (efflux transporters)
SLC transport phenotyping (uptake transporters)
Peptide based uptake transport phenotyping (PEPT1/2, SMVT)
SLC transport phenotyping in Xenopus oocytes (OATPs, OATs, OCTs, MATEs)
Cryopreserved hepatocytes uptake
Hepatic excretion by Sandwich cultured hepatocytes
Enzyme Inhibition CYP Inhibition (Screening, IC50 assay)
CYP inhibition (Ki assay)
UGT Inhibition (Screening, IC50 assay)
UGT inhibition (Ki assay)
Time-Dependent Inhibition (IC50 shift assay)
Time-Dependent Inhibition (Ki and Kinact)
Transporter Inhibition ABC transporter inhibition (efflux transporters_accumulation)
ABC transporter inhibition (efflux transporters_bi-direction)
SLC transporter inhibition (uptake transporters)
Time-dependent inhibition of OATP, IC50 shift assay
Enzyme/Transporter Induction Cell viability
Transporter (CYPs, UGTs, Transporters) Induction
Enzyme activity in human hepatocytes
Enzyme Induction (EC50 assay)
BCS-Biowaiver Solubility
Chemical stability
Caco-2 cell permeability
Bioanalytical service Method development
Method validation
Sample analysis
PK analysis
- Radiolabeled clinical ADME studies (Mass balance, Metabolite profiling & Identification)

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