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  • 비임상ADME
  • 서비스항목

서비스항목

에스피메드는 고객의 건강을 우선으로 생각하는 기업입니다

대분류 소분류 요소기술
Permeability Drug absorption Caco-2 cells Permeability Assay
Parallel artificial membrane permeability assay (PAMPA)
Hepatic excretion Sandwich cultured hepatocytes
Plasma protein binding Protein binding Plasma protein binding assay (Equilibrium dialysis)
Drug metabollism Metabolic stabililty Microsomal stability assay
S9 stability assay
Hepatocyte stability assay
Plasma stability
Species comparison (mouse, rat, dog, monkey, human)
Reaction phenotyping Phase I (CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 3A4, 3A5 etc.)
Phase II (UGT1A1, 1A3, 1A4, 1A6, 1A9, 2B7, 2B15)
Phase I (Non-CYPs, FMO, CES, MAO etc.)
Enzyme systems in the test (Recombinant enzymes, Microsomes, S9, Hepatocytes)
Kinetic studies (Km, Vmax, intrinsic clearance)
Pharmocogenetics study (CYP2C19*10, 2D6*10B, 4F2*3)
Met ID Metabolites profiling and Met ID
Drug transporters Transporter substrate identification Uptake transport screening in overexpressing cells or oocytes (OCTs, OATs, OATPs, MATEs)
Efflux transport screening in overexpressing cells (P-gp, BCRP, MRP1, MRP2)
Cryopresesrved hepatocytes uptake
Kinetic studies (Km, Vmax, intrinsic clearance)
Pharmacogenetics study (OCT2 A270S, OATP1B1*15, NTCP*2, MDR1 G2677T/A, BCRP Q141K)
Drug-Drug interaction Metabolizing enzyme inhibition Cytochrome P450 (CYP) inhibition assay (IC50)
UGT inhibition assay (IC50)
Cytochrome P450 Inhibition Ki assay
Time-dependent inhibition Cytochrome P450 (CYP) time dependent inhibition (single point) assay
Cytochrome P450 time dependent inhibition (IC50 shift) assay
Cytochrome P450 time dependent inhibition (kinact/KI) assay
GSH conjugate (reactive metabolite)
Transporter inhibition P-glycoprotein and BCRP Inhibition assay
BSEP, MRP1, MRP2 Inhibition assay
Uptake transport inhibition in overexpressing cells or oocytes (OCTs, OATs, OATPs, NTCP)
Induction mRNA expression level in human hepatocytes (CYPs, UGTs, Transporters)
CYP activity in human hepatocytes
Reporter assay (PXR)
In vitro to in vivo Extrapolation IVIVE prediction
Preclinical study Linearity / Bioavailability IV/Oral administration PK
Mass balance Radio-labeled compound PK
Distribution Tissue distribution (brain, liver, kidney...)
Met ID Metabolites profiling and Met ID
Billiary /Renal excretion Bile cannulation
Bioanalytical services - -

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