| Permeability | Permeability | |
Caco-2 cells permeability |
|
MDCK cells permeability |
|
PAMPA membrne Permeability |
| Plasma protein binding | Plasma protein binding | |
Plasma protein binding assay |
| Drug metabollism | Metabolic stabililty | |
Plasma stability |
|
Microsomal stability |
|
Hepatocyte stability |
| Metabolite profiling & ID | |
Metabolite profiling & ID |
| Drug metabollism Reaction phenotyping | |
Reaction phenotyping for CYP (recombinant CYPs) |
|
Reaction phenotyping for UGT (recombinant UGTs) |
| Drug transporter | Drug transporter Reaction phenotyping | |
Reaction phenotyping for Transport |
|
Reaction phenotyping for Transport (Kinetic study) |
| Drug-Drug interaction | Enzyme Inhibition | |
CYP Inhibition (Screening of CYP inhibition) |
|
CYP inhibition (IC50 assay) |
|
CYP inhibition (Ki assay) |
|
UGT Inhibition (Screening of UGT inhibition) |
|
UGT Inhibition (IC50 assay) |
|
UGT inhibition (Ki assay) |
|
Time-Dependent Inhibition (IC50 shift assay) |
|
Time-Dependent Inhibition (Kinact/KI assay) |
|
Microsomal binding assay |
| Transporter Inhibition | |
Transporter Inhibition (Screening) |
|
Transporter Inhibition (IC50 assay) |
|
Transporter Inhibition (Ki assay) |
|
Transporter inhibition (Time-Dependent Inhibition, IC50 shift assay) |
| Enzyme/Transporter Induction | |
Enzyme/Transporter Induction |
|
Enzyme Induction (EC50 assay) |
|
PXR reporter assay |
|
Cell viability |
| Bioanalytical services | Bioanalytical service | |
약물분석법개발 |
|
In vivo PK 혈장 분석 |
| Preclinical study |
- |
|
- |
